APPLICATION OF MICRORNA-210 INHIBITOR IN THE PREPARATION OF DRUGS FOR TREATING INFLAMMATORY SKIN DISEASES

摘要

Disclosed is application of a microRNA-210 inhibitor in the preparation of drugs for treating inflammatory skin diseases. The present inventor has demonstrated in a large number of experiments that in vitro inhibition of microRNA-210 expression can significantly enhance the expression of target gene STAT6 of microRNA-210, thereby inhibiting the proliferation of keratinocytes and the secretion of chemokine CCL20, further inhibiting chemotactic T cell migration towards a skin lesion part, and also inhibiting the differentiation of T_H1 and T_H17. MicroRNA-210 knockout and intradermal injection of a microRNA-210 inhibitor (cholesterol-modified antagomir-210) on a skin lesion specifically inhibit the expression of microRNA-210, so that skin inflammation in mice can be significantly inhibited and T cell immune imbalance is mitigated. The present invention provides a new pathophysiological mechanism for inflammatory skin diseases and provides a new strategy for preparing drugs for treating inflammatory skin diseases.