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METHODS AND COMPOSITIONS FOR USE OF TUMOR SELF-ANTIGENS IN ADOPTIVE IMMUNOTHERAPY

机译：在自适应免疫治疗中使用肿瘤自体抗原的方法和组合物

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摘要

The present disclosure provides methods and compositions for immunotherapy employing a modified T cell or NK cell comprising a receptor that binds to newly identified tumor antigens that can be administered to patients for disease (e.g., cancer) treatment. Also described are polynucleotides and vectors encoding the same.

机译：本公开提供了使用修饰的T细胞或NK细胞进行免疫疗法的方法和组合物，所述修饰的T细胞或NK细胞包含与新近鉴定的肿瘤抗原结合的受体，该受体可以施用于患者以治疗疾病（例如，癌症）。还描述了多核苷酸和编码该多核苷酸的载体。 展开▼

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公开/公告号WO2019178081A1

专利类型

公开/公告日2019-09-19

原文格式PDF

申请/专利权人 THE CHILDRENS HOSPITAL OF PHILADELPHIA;
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申请/专利号WO2019US21827

发明设计人 MARIS JOHN M.;YARMARKOVICH MARK;
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申请日2019-03-12

分类号A61K39;C07K14/47;C07K16/18;C07K16/22;C12N15/09;

国家 WO

入库时间 2022-08-21 11:53:10

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1. 使用经修饰的肿瘤细胞和经修饰的树突细胞增强肿瘤免疫原性的方法和用于自体癌症免疫治疗产品的组合物 [P] . 中国专利： CN110392574A . 2019-10-29

2. 新抗原肽组合物及其在肿瘤免疫治疗药物中的应用 [P] . 中国专利： CN112142837A . 2020-12-29

3. METHODS AND COMPOSITIONS FOR USE OF TUMOR SELF-ANTIGENS IN ADOPTIVE IMMUNOTHERAPY [P] . US2021213058A1 . 2021-07-15

机译：使用肿瘤自我抗原在养护免疫疗法中的方法和组合物

4. Methods and compositions for use of tumor self-antigens in adoptive immunotherapy [P] . AU2019234576A1 . 2020-10-08

机译：在过继免疫疗法中使用肿瘤自身抗原的方法和组合物

5. Method and composition for use of tumor autoantigen in adoptive immunotherapy [P] . JP2021517810A . 2021-07-29

机译：用于使用肿瘤自身的方法和组合物在采用免疫疗法中的使用

1. Ex vivo expansion of tumor-infiltrating lymphocytes from nasopharyngeal carcinoma patients for adoptive immunotherapy [J] . Jia He, Xiao-Feng Tang, Qiu-Yan Chen, 癌症（英文版） . 2012,第006期

2. The status, limitation and improvement of adoptive cellular immunotherapy in advanced urologic malignancies [J] . Haoqing Shi, Xiangjie Qi, Bin Ma, 中国癌症研究（英文版） . 2015,第002期

3. Leveraging TCR Affinity in Adoptive Immunotherapy against Shared Tumor/Self-Antigens [J] . Miller Aaron M., Bahmanof Milad, Zehn Dietmar, Cancer immunology research. . 2019,第1期

4. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors [J] . Cozza Eugene M., Cooper Timothy K., Budgeon Lynn R., Cancer immunology, immunotherapy : . 2015,第3期

5. Adoptive Immunotherapy of Advanced Tumors with CD62 L-Selectin(low) Tumor-Sensitized T Lymphocytes Following Ex Vivo Hyperexpansion. [J] . Wang LX, Chen BG, Plautz GE The Journal of Immunology: Official Journal of the American Association of Immunologists . 2002,第6期

6. ANTITUMOR ACTIVITY OF PHOTODYNAMIC THERAPY, ADOPTIVE IMMUNOTHERAPY AND CHEMOTHERAPY IN EXPERIMENTAL TUMOR [C] . Gianfranco Canti, Angela Calastretti, Rinaldo Cubeddu, Society of Photo-Optical Instrumentation Engineers Conference on Laser Interaction with Tissue and Cells . 2004

7. Targeting a self/tumor antigen expressed in the prostate for adoptive T cell immunotherapy of prostate cancer. [D] . Chou, Cassie K. 2012

8. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors [O] . Eugene M. Cozza, Timothy K. Cooper, Lynn R. Budgeon, -1

9. Protection from tumor recurrence following adoptive immunotherapy varies with host conditioning regimen despite initial regression of autochthonous murine brain tumors [O] . Eugene M. Cozza, Timothy K. Cooper, Lynn R. Budgeon, 2014

10. Adoptive Immunotherapy for Epithelial Ovarian Cancer Using T-cells Simultaneously Targeted to Tumor and Tumor-Associated Macrophages. [R] . Maher, J., Ghaem-Maghami, S. 2013

1. Immunotherapy of melanoma metastasis by adoptive transfer of M-CSF or/and IFN-γ gene modified macrophages pulsed with tumor extracts [J] . Hong Lei Yizhi Yu Xuetao CaoDepartment of Immunology The Second Military MedicalUniversity Shanghai 200433 . 中国实验血液学杂志 . 1997,第3期

2. Prolonged overall survival in gastric cancer patients after adoptive immunotherapy [J] . Guo-Qing Zhang ,Hong Zhao ,Jian-Yu Wu . 世界胃肠病学杂志：英文版 . 2015,第9期

3. Adoptive immunotherapy for acute leukemia:New insights in chimeric antigen receptors [J] . Mael Heiblig ,Mohamed Elhamri ,Mauricette Michallet . 世界干细胞杂志：英文版（电子版） . 2015,第7期

4. 肿瘤免疫治疗中肿瘤抗原研究进展 [C] . 熊松柏 ,李鲁 ,林毅 . 2010年北京胸外科年会 . 2010

5. 消化道肿瘤姑息性术后自体抗原致敏DC-CIK过继转移治疗方法的建立与临床应用研究 [A] . 张效东 . 2009