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MIR-17~92 AS THERAPEUTIC OR DIAGNOSTIC TARGET OF MOTOR NEURON (MN) DEGENERATION DISEASES

机译：MIR-17〜92作为神经退行性疾病的治疗或诊断目标

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摘要

The present disclosure relates to mir-17~92 as a candidate therapeutic or diagnostic target of motor neuron (MN) degeneration diseases. Expression of mir-17~92 is sustained throughout adulthood in spinal MNs and specifically decreases before the onset of MN loss in SOD1_G93A mice. Accordingly, mir-17~92 can be used as a candidate therapeutic target for ALS.

机译：本公开涉及作为运动神经元（MN）变性疾病的候选治疗或诊断靶标的 mir-17〜92 。 mir-17〜92 的表达在整个成年期在脊髓MN中持续存在，并且在 SOD1 _{G93A 中在MN丧失开始之前特别降低。小鼠。因此， mir-17〜92 可用作ALS的候选治疗靶标。} 展开▼

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公开/公告号WO2019195304A1

专利类型

公开/公告日2019-10-10

原文格式PDF

申请/专利权人 ACADEMIA SINICA;SHIH MING-CHE;
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申请/专利号WO2019US25406

发明设计人 CHEN JUN-AN;PENG KUAN-CHIH;TUNG YING-TSEN;
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申请日2019-04-02

分类号A61K31/7105;A61K9;A61K9/51;A61K47/46;A61P25;A61P21;C12Q1/6883;

国家 WO

入库时间 2022-08-21 11:52:54

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1. MIR-17~92作为运动神经元(MN)退化疾病的治疗或诊断目标 [P] . 中国专利： CN112292134A . 2021-01-29

2. 对由神经退行性疾病、肌肉退行性疾病、或神经-肌肉退行性疾病所致的组织退化、伤害或损伤进行治疗或预防的方法、或对受到所述疾病的不利影响的组织进行恢复的方法 [P] . 中国专利： CN101102784A . 2008-01-09

3. MIR-17˜92 AS THERAPEUTIC OR DIAGNOSTIC TARGET OF MOTOR NEURON (MN) DEGENERATION DISEASES [P] . US2021145859A1 . 2021-05-20

机译： miR-17~92作为运动神经元（Mn）变性疾病的治疗或诊断靶标

4. MIR-17~92 AS THERAPEUTIC OR DIAGNOSTIC TARGET OF MOTOR NEURON (MN) DEGENERATION DISEASES [P] . EP3773606A4 . 2021-12-08

机译： MiR-17〜92作为运动神经元（Mn）变性疾病的治疗或诊断靶标

5. NOR-1 (NEURON-DERIVED ORPHAN RECEPTOR-1), NOVEL DIAGNOSTIC AND THERAPEUTIC TARGET FOR CARDIOVASCULAR DISEASES [P] . ES2288330A1 . 2008-01-01

机译： NOR-1（神经源性ORPHAN受体1），新型诊断和治疗靶点，用于治疗心血管疾病

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