HYDROPHILIC BERBERINE DERIVATIVE WITH R₁₀ AND R₁₁ CONNECTED AND APPLICATION THEREOF IN PREPARATION OF DRUGS

摘要

Disclosed are an 8-dihalide methyl berberine quaternary ammonium compound shown in formulas (I) and (II), a synthetic method therefor, and an application thereof in preparation of drugs. The 8-dihalide methyl berberine quaternary ammonium compound is more hydrophilic than a substrate in the absence of conventional hydrophilic groups. The 8-dihalide methyl berberine quaternary ammonium compound has a remarkable anti-microbial activity, anti-inflammatory activity and anti-ulcerative colitis activity, can explicitly and significantly regulate target molecules, associated with tumor formation, in tumor cells of the colon cancer, liver cancer, lung cancer, breast cancer, osteosarcoma, and glioma, and has anti-tumor activity. The pharmacological action of the compound of the present invention is higher than that of a control drug. Moreover, the compound has the characteristics of nontoxicity or hypotoxicity, and can be used for preparing drugs for preventing, alleviating, and/or treating microbiological contamination, inflammation, ulcerative colitis, and tumors.