INTEGRATED DEVICES TO CONTINUOUSLY MEASURE BOUND AND UNBOUND ANALYTE FRACTIONS IN BIOFLUIDS

摘要

Embodiments of the disclosed invention provide devices for measuring concentrations of bound and unbound fractions of a target analyte in a biofluid sample. Analytes present in biofluid may be found in a free state, or bound to a binding solute, presenting difficulties for wearable analyte sensors to measure physiologically significant concentrations of the analyte in biofluid. The disclosed devices feature sensors configured to measure both the bound and unbound fractions of the analyte, as well as analyte releasers that cause a portion of the bound fraction of analytes to be released to facilitate measurement. Some embodiments include a collector and or a sample conduit. Other embodiments include a plurality of fluid pathways.