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Mehtod of Screening an Inhibitor for Metastasis of Colorectal Cancer

机译:筛选结直肠癌转移抑制剂的方法

摘要

The present invention relates to a method for screening an inhibitor for colorectal cancer metastasis, and an inhibitor for colorectal cancer metastasis screened by the method. The present invention relates to a method for screening an inhibitor for colorectal cancer metastasis, and an inhibitor for colorectal cancer metastasis screened by the method. Specifically, the present invention relates to a method for screening an inhibitor for colorectal cancer metastasis, including a step of screening the inhibitor for colorectal cancer metastasis through the interaction between chemokine (C-C motif) ligand 7 (CCL7) and C-C chemokine receptor type 3 (CCR3) and a change in the expression of epithelial-mesenchymal transition (EMT)-involved factors and/or mitogen-activated protein kinase (MAPK) pathway-involved factors.
机译:本发明涉及大肠癌转移抑制剂的筛选方法以及通过该方法筛选的大肠癌转移抑制剂。本发明涉及大肠癌转移抑制剂的筛选方法以及通过该方法筛选的大肠癌转移抑制剂。具体而言,本发明涉及一种筛选结直肠癌转移抑制剂的方法,包括通过趋化因子(CC基序)配体7(CCL7)和CC趋化因子受体3型之间的相互作用筛选结直肠癌转移抑制剂的步骤( CCR3)和上皮-间质转化(EMT)相关因子和/或促分裂原活化蛋白激酶(MAPK)通路相关因子的表达变化。

著录项

  • 公开/公告号KR20180126418A

    专利类型

  • 公开/公告日2018-11-27

    原文格式PDF

  • 申请/专利权人 SAMSUNG LIFE PUBLIC WELFARE FOUNDATION;

    申请/专利号KR20180141574

  • 发明设计人 CHO YONG BEOM;LEE WOO YONG;

    申请日2018-11-16

  • 分类号C12Q1/6886;G01N33/50;

  • 国家 KR

  • 入库时间 2022-08-21 11:52:24

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