Combination therapy of Notch and PI3K / mTOR inhibitors for use in cancer therapy

摘要

[(7S) -5- (2-hydroxyethyl) -6-oxo-7H-pyrido [2,3- d] pyrimidin- 7-yl] amino] -1-methyl-2-oxo-ethyl] butanamide or a pharmaceutically acceptable salt or hydrate thereof and 8- [5- (1-hydroxy- -Methylethyl) pyridin-3-yl] -1 - [(2S) -2-methoxypropyl] -3-methyl- 1, 3- dihydro-2H- imidazo [4,5- c] quinoline- T-cell acute lymphoblastic leukemia, acute lymphoblastic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, breast cancer, ovarian cancer, melanoma, or a combination thereof, A medicament for use in the treatment of a tumor, lung cancer, pancreatic cancer, glioblastoma, sarcoma, desmoid tumor, adenocystic carcinoma, colorectal cancer, head and neck cancer, cervical cancer, prostate cancer, liver cancer or skin cancer.