Urinary mRNA for non-invasive differential diagnosis of acute rejection in kidney transplanted patients and uses thereof

摘要

The present invention relates to a noninvasive biomarker for diagnosing acute rejection to kidney transplantation and a use thereof and, more specifically, relates to a marker composition for diagnosing acute rejection to kidney transplantation, including mRNA of at least one gene selected as a marker from a group comprising C1QB, CD3ε, CXCL9, IP-10, Tim-3, PSMB9, and combinations thereof, a method of providing necessary information for diagnosing acute rejection to kidney transplantation by using the marker composition, a diagnosing composition including a medicine for measuring an expression level of the marker, and a diagnosing kit including a quantitative device for the marker. According to the present invention, mRNA of C1QB, CD3ε, CXCL9, IP-10, Tim-3, and/or PSMB9 genes exists at a high level in the urine of a patient with acute rejection to kidney transplantation, and thus, the present invention is able to be conveniently used for diagnosing acute rejection to kidney transplantation through a noninvasive method.