Urinary mRNA for non-invasive differential diagnosis of acute rejection in kidney transplanted patients and uses thereof

摘要

The present invention relates to a biomarker for noninvasively diagnosing acute rejection of kidney transplantation and a use thereof, and more particularly, to: a marker composition for diagnosing acute rejection of kidney transplant, the marker composition comprising, as a marker, mRNA of at least one gene selected from the group consisting of C1QB, CD3ε, CXCL9, IP-10, Tim-3, PSMB9, and a combination thereof; a method for providing information necessary for diagnosing acute rejection of kidney transplantation using the marker composition; a method for providing information necessary for diagnosing acute rejection of kidney transplantation using the marker composition; a diagnostic composition comprising an agent for measuring the expression level of the marker; and a diagnostic kit comprising a quantitative device for the marker. mRNA of C1QB, CD3ε, CXCL9, IP-10, Tim-3 and/or PSMB9 genes according to the present invention is present at a high level in the urine of patients, and thus may be used for conveniently diagnosing acute rejection of kidney transplantation in a noninvasive way.