Compositions and methods for targeted particle penetration, distribution, and response in malignant brain tumors

摘要

Nanoparticle conjugates for the treatment of cancer, for example, which exhibit enhanced penetration of tumor tissue (e. G., Brain tumor tissue) and proliferation in inter-tumor vasculature are described herein. Methods of targeting tumor-associated macrophages, microglia, and / or other cells in tumor microenvironment using such nanoparticle conjugates are further described. In addition, diagnostic, therapeutic, and theranostic (diagnostic and therapeutic) platforms featuring such nanoparticle conjugates can be used to treat targets in both tumors and the surrounding microenvironment, thereby enhancing the efficacy of cancer therapy . The use of the nanoparticle conjugates described herein in conjunction with other conventional therapies, including chemotherapy, radiation therapy, immunotherapy, etc., is also contemplated.