Compositions and methods for penetration, distribution and response of targeted particles in malignant brain tumors

摘要

For example, nanoparticle conjugates are described herein that exhibit enhanced penetration into tumor tissue (eg, brain tumor tissue) and diffusion within tumor stroma for the treatment of cancer. Furthermore, methods of targeting tumor associated macrophages, microglia and / or other cells in tumor microenvironments using such nanoparticle conjugates are described. In addition, diagnostic, therapeutic, and theranostic (diagnostic and therapeutic) platforms featuring such nanoparticle conjugates have been described for treating targets in both the tumor and surrounding microenvironments. , Enhance the effectiveness of cancer treatment. It is also envisioned to use the nanoparticle conjugates described herein with other conventional therapies, including chemotherapy, radiation therapy, immunotherapy and the like.