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SNP SNP for diagnosing fibromyalgia microarray and kit comprising the same
SNP SNP for diagnosing fibromyalgia microarray and kit comprising the same
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机译:用于诊断纤维肌痛微阵列的SNP SNP及包含该SNP的试剂盒
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摘要
The present invention is to screen single nucleotide polymorphism (SNP) of endothelin-1 (EDN1) gene having a significant correlation with fibromyalgia and predict the risk of occurrence of fibromyalgia by using the same as a marker. More specifically, the present invention relates to: an SNP for diagnosing fibromyalgia comprising a polynucleotide, comprising a 502^nd base and consisting of at least 8 consecutive bases, in the polynucleotide of SEQ ID NO: 1 as a complementary sequence of rs1800541 forming a part of endoserine-1 gene, or a complementary polynucleotide thereof; a microarray for diagnosing fibromyalgia comprising the polynucleotide, a polypeptide encoded by the same, or cDNA thereof; and a kit including the same.
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机译:本发明用于筛选与纤维肌痛具有显着相关性的内皮素-1(EDN1)基因的单核苷酸多态性(SNP),并通过将其用作标记物来预测发生纤维肌痛的风险。更具体地,本发明涉及用于诊断纤维肌痛的SNP,其在SEQ ID NO:1的多核苷酸中包含多核苷酸,该多核苷酸包含502 nd碱基并且由至少8个连续碱基组成,作为rs1800541的互补序列,形成Endoserine-1基因的一部分,或其互补的多核苷酸;诊断纤维肌痛的微阵列,其包含多核苷酸,由其编码的多肽或其cDNA。以及包含该套件的套件。
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