FUSION PROTEIN INCLUDING EPITOPES DERIVED FROM FOOT-AND-MOUTH DISEASE VIRUS AND VIRUS-LIKE PARTICLE INCLUDING THEREOF

摘要

Disclosed is a fusion protein including a peptide consisting of a cytoplasmic inner tail region and a transmembrane region of hemagglutinin protein, and at least one epitope of amino acid position 132-162 of VP1 derived from a foot-and-mouth disease virus and an epitope of amino acid position 192-211 of VP1 derived from a foot-and-mouth disease virus, respectively. Also, disclosed is a virus-like particle comprising an envelope and a particle consisting of the fusion protein and an influenza virus M1 protein. The virus-like particle can be manufactured to be used in vaccines, which are safer than attenuated and inactivated vaccines, and can induce an immune response more effective than subunit vaccines.