FUSION PROTEIN INCLUDING EPITOPES DERIVED FROM FOOT-AND-MOUTH DISEASE VIRUS AND VIRUS-LIKE PARTICLE INCLUDING THEREOF

摘要

At least one antigenic determining site at amino acid positions 132-162 of foot and mouth virus origin VP1 and at least one antigenic determining site at amino acid positions 192-211 of foot and mouth virus derived VP1; And a fusion protein comprising a peptide consisting of a transmembrane region and a cytoplasmic internal tail region of a hemagglutinin protein, and a virus-like particle comprising particles and envelopes composed of the fusion protein and influenza virus M1 protein. The virus like particles can be prepared and used in vaccines, which are safer than attenuated and inactivated vaccines, and can induce an immune response more effective than subunit vaccines.