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- prodrug conjucation for targeted tumor manufacturing method thereof pharmaceutical composition for treating and preventing tumor comprising thereof

机译:-用于靶向肿瘤的前药结合物的制备方法,用于治疗和预防肿瘤的药物组合物,包括其

摘要

The present invention relates to a tumor recognition-type photosensitizer-drug conjugate. More specifically, the tumor recognition-type photosensitizer-drug conjugate has excellent specific activity on tumor tissues, is effectively accumulated on tumor tissues, and has an advantage of effectively exerting efficacy of an anticancer drug with little systemic toxicity since DEVD peptides is cleaved by caspase-3 so that a drug is released locally in a form of a prodrug.
机译:本发明涉及肿瘤识别型光敏剂-药物缀合物。更具体地,所述肿瘤识别型光敏剂-药物缀合物在肿瘤组织上具有优异的比活性,在肿瘤组织上有效地积聚,并且由于DEVD肽被胱天蛋白酶裂解,因此具有有效发挥抗癌药功效而几乎没有全身毒性的优点。 -3,以便药物以前药的形式局部释放。

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