A Metal-free Nanozyme-activated Prodrug Strategy for Targeted Tumor Catalytic Therapy

摘要

Enzyme prodrug therapy,which was introduced in 1985,is an attractive strategy for targeted cancer therapy with low systemic toxicity.The prodrug itself is low-toxic or non-toxic,after it was ingested,the enzyme can selectively activate the prodrug at the site of the lesion,thus enhancing the pharmacological effect and reducing the side effects.