COMPOSITION FOR TREATMENT AND PREDICTING PROGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA

摘要

The present invention relates to a pharmaceutical composition for preventing or treating head and neck cancer, including a LAMB3 inhibitor, and a method for predicting or diagnosing onset and prognosis of head and neck cancer, wherein LAMB3 genes and proteins are overexpressed in tissue and cell lines of head and neck cancer patients, inhibition of LAMB3 Inhibits the migration and invasion of head and neck cancer cells, the combination of cisplatin, which exhibits resistant to LAMB3 inhibition and head and neck cancer treatment, shows significant synergistic effects, and the expression of LAMB3 is specific for prognostic determination of head and neck cancer. Therefore, the LAMB3 inhibitor can be sued for treatment, prevention, diagnosis, and prognosis of head and neck cancer.