PKR PYRROLOPYRROLE COMPOSITIONS AS PYRUVATE KINASE PKR ACTIVATORS

摘要

The present invention relates to the regulation of pyruvate kinases and provides novel compounds of formula (I) useful as activators of PKR as well as various uses of these compounds. PKR activating compounds are useful for the treatment of diseases and disorders associated with PKR and / or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia: Formula (I)] .