Composition for differentiation of periodontal ligament cells to Cementoblast

摘要

The present invention relates to a kit, a medium and a composition for inducing differentiation of periodontal ligament cells into cementoblasts, including transforming growth factor-beta (TLG-β) receptor activin receptor-like kinase (ALK) 5 inhibitors; and a method for inducing differentiation using the same. According to the present invention, by separating periodontal ligament cells from human adult periodontal ligament cells and treating the periodontal ligament cells with a TGF-β receptor ALK5 inhibitor, it is possible to effectively induce differentiation of periodontal ligament cells into target cells, cementoblasts, and by securing cementoblasts required for the successful regeneration of periodontal tissue, the present invention can be used to study regeneration and formation of cement and to find surface expression markers specific thereto.