PKC-LSD1-NFB Method of screening agents modulating inflammation by targeting PKC-LSD1-NFB pathway

摘要

The present application discloses a method for screening an inflammation modulating agent by targeting PKCα-LSD1-NF-κB. In response to excessive inflammatory stimuli, PKCα migrates to the nucleus to phosphorylate LSD1. LSD1 phosphorylation is required for p65 binding and promotes demethylation of p65 to enhance the stability of p65 protein. Therefore, the method according to the present application can be usefully used for the development of a therapeutic agent for systemic inflammatory diseases including sepsis through the inhibition of PKCα or LSD1 activity.