Immunogenic compositions against human progastrin peptides

摘要

Immunogens for human expansion-progastrinoma species include: (B) an immunogenic carrier; (ii) an N-terminal and / or C-terminal processing species of progastrin or progastrin (i) (A) / RTI Exemplary mimetic peptide / spacer combinations are 21 amino acid peptides (SEQ ID NO: 1) and other, associated polypeptides (SEQ ID NO: 2-5). Pharmaceutical compositions containing such immunogens exhibit improved immunological properties, including inducing an effective antibody level immediately upon administration of an initial course of immunogen. The level of antibody so induced can be maintained elevated for several months and easily elevated to a higher level upon subsequent amplification by a single injection of an immunogen.