IL-15 IL-15R AN IL-15 AND IL-15R SUSHI DOMAIN BASED IMMUNOCYTOKINES

摘要

The present invention relates to an immunocytokine comprising (a) a conjugate, and (b) an antibody or fragment thereof covalently or directly bonded to the conjugate, wherein the conjugate comprises (i) an interleukin 15 or derivative thereof , And (ii) a polypeptide comprising the amino acid sequence of the sushi domain of IL-15Ra or a derivative thereof. The invention also relates to the use of said immunocytokines.