RNA LIPID FORMULATIONS FOR DELIVERY OF MESSENGER RNA

摘要

The present invention provides, among other things, to a subject in need of delivery a composition comprising an mRNA encoding a protein encapsulated within a liposome, whereby delivery of the composition results in a protein encoded by the mRNA in vivo. Provided are methods for delivering mRNA in vivo, including expression, wherein the liposomes comprise cationic lipids of Formula Ic: Or pharmaceutically acceptable salts thereof.