An antibody against MERS-CoV and method of determining titration for antibody to MERS-CoV using the same

摘要

The present invention relates to a recombinant spike protein antigen of Middle East Respiratory Syndrome Coronavirus (MERS-CoV). More specifically, recombinant baculovirus and recombinant baculovirus prepared by co-infecting a recombinant expression vector including a receptor binding domain (RBD), which is part of a spike (S) protein of MERS-CoV, with a baculovirus DNA, The present invention relates to recombinant spike protein fragments (RBDs) obtained by infecting host cells, monoclonal antibodies, and methods for producing the same. In addition, the present invention relates to an immunoassay based virus antibody titer measurement technique using MERS-CoV recombinant S-RBD protein.