8-CARBAMOYL-2-23-DISUBSTITUTED PYRID-6-YL-1234-TETRAHYDROISOQUINOLINE DERIVATIVES AS APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES

摘要

The present invention is directed to a compound that inhibits the activity of an anti-apoptotic Bcl-xL protein, a composition comprising the compound, and a method for treating a disease, such as cancer, in which an anti-apoptotic Bcl-xL protein is expressed during a disease. It is about. Formula I In Formula I, X is heteroaryl; Y ¹ is phenylene or C _5-6 heteroarylene; L ¹ is a linker; Y ² is cycloalkyl, cycloalkenyl, heterocycloalkyl, or heterocycloalkenyl; Z ¹ is C (O) OR ⁹ , C (O) NR ¹⁰ R ¹¹ , C (O) R ¹¹ , NR ¹⁰ C (O) R ^11, and the like.