首页> 外国专利> TARGET GENE SCREENING METHOD AND APPARATUS BASED MULTI-OMICS DATA AND SURVIVAL ANALYSIS

TARGET GENE SCREENING METHOD AND APPARATUS BASED MULTI-OMICS DATA AND SURVIVAL ANALYSIS

机译:基于目标基因的多基因组数据筛查方法和装置及生存分析

摘要

According to the present invention, a target gene screening method using survival analysis comprises the steps of: receiving multi-omics data about whole-genome; selecting a plurality of genes amplified above a reference value based on gene expression data included in the multi-omics data and determining a degree of association with a specific disease for each of the selected genes; and mathematically processing the degree of association and a correlation between the expression of the selected gene and the number of gene copies of the selected gene for each of the selected genes to determine a target score. A maximum significance boundary value for each gene is determined based on survival data included in the multi-omics data, and a target gene is selected from the genes filtered based on the maximum significance boundary value.
机译:根据本发明,使用存活分析的靶基因筛选方法包括以下步骤:接收有关全基因组的多组学数据;以及基于多组学数据中包括的基因表达数据,选择扩增到参考值以上的多个基因,并为每个选择的基因确定与特定疾病的关联度;以及数学地处理每个所选基因的所选基因的表达与所选基因的基因拷贝数之间的关联度和相关性,以确定目标得分。基于多组学数据中包括的存活数据确定每个基因的最大重要性边界值,并且从基于最大重要性边界值过滤的基因中选择靶基因。

著录项

  • 公开/公告号KR102042242B1

    专利类型

  • 公开/公告日2019-11-07

    原文格式PDF

  • 申请/专利权人 INSILICOGEN INCORPORATION;

    申请/专利号KR20180075201

  • 发明设计人 KONG GU;KIM HYUNG YONG;LEE JEONG YEON;

    申请日2018-06-29

  • 分类号G16B30;C12Q1/6886;

  • 国家 KR

  • 入库时间 2022-08-21 11:47:24

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