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SUPPRESSING ERRORS IN SEQUENCED DNA FRAGMENTS BY USING EXCESSIVE READING WITH UNIQUE MOLECULAR INDICES (UMI)
SUPPRESSING ERRORS IN SEQUENCED DNA FRAGMENTS BY USING EXCESSIVE READING WITH UNIQUE MOLECULAR INDICES (UMI)
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机译:通过使用独特的分子指数(UMI)进行大量阅读来抑制测序DNA片段中的错误
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摘要
The disclosed embodiments concern methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index (UMI) sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length. In some implementations, the UMIs include both physical UMIs and virtual UMIs. In some implementations, the unique molecular index sequences include non-random sequences. System, apparatus, and computer program products are also provided for determining a sequence of interest implementing the methods disclosed.
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