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RECOMBINANT PLASMID pHis6-flagG-protE, WHICH PROVIDES SYNTHESIS OF A RECOMBINANT CHIMERIC PROTEIN, INCLUDING EPITOPES OF GLYCOPROTEIN E OF TICK-BORNE ENCEPHALITIS VIRUS AND FLAGELLIN G SALMONELLA TYPHII AND USED AS A BASE FOR VACCINE AGAINST TICK-BORNE ENCEPHALITIS VIRUS
RECOMBINANT PLASMID pHis6-flagG-protE, WHICH PROVIDES SYNTHESIS OF A RECOMBINANT CHIMERIC PROTEIN, INCLUDING EPITOPES OF GLYCOPROTEIN E OF TICK-BORNE ENCEPHALITIS VIRUS AND FLAGELLIN G SALMONELLA TYPHII AND USED AS A BASE FOR VACCINE AGAINST TICK-BORNE ENCEPHALITIS VIRUS
FIELD: biotechnologies.SUBSTANCE: invention relates to the biotechnology. Described is a recombinant plasmid pHis6-flagG-protE with built-in fliG and TBEVgp1 genes coding hybrid recombinant flagG-protE protein inducing an immune response to tick-borne encephalitis virus.EFFECT: invention provides production of recombinant chimeric protein without inclusion bodies formation, provides synthesis of recombinant chimeric protein having amino acid sequence (SEQ ID NO: 2), including epitopes of glycoprotein E of tick-borne encephalitis virus and flagellin G Salmonella typhii and used as a base for vaccine against tick-borne encephalitis virus.1 cl, 5 dwg, 2 tbl, 4 ex
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机译:技术领域本发明涉及生物技术。描述了一种重组质粒pHis6-flagG-protE,其具有内置的fliG和TBEVgp1基因,该基因编码杂交的重组flagG-protE蛋白,可诱导对tick传脑炎病毒的免疫应答。提供了具有氨基酸序列(SEQ ID NO:2)的重组嵌合蛋白的合成,包括tick传脑炎病毒和鞭毛蛋白G型鼠伤寒沙门氏菌的糖蛋白E的表位,并用作抗tick传脑炎病毒的疫苗的基础。1cl ,5载重吨,2汤匙,4前
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