DIAGNOSTIC TECHNIQUE IN CHILDREN OF ASTHENIC-VEGETATIVE SYNDROME UNDER EXPOSURE CONDITIONS WITH ALUMINUM

摘要

FIELD: medicine.;SUBSTANCE: what is presented is a diagnostic technique in children of asthenic-vegetative syndrome under conditions of aluminum exposure. Content of aluminum is determined in urine sample of child. DNA is extracted from buccal epithelium sample. Then, genotyping of polymorphism of genotypes of glutamate ion receptor GRIA1 (rs545098) and glial glutamate transporter gene SLC2A1 (rs841839) is carried out on a detecting polymerizer using real-time polymerase chain reaction. If observing the following conditions simultaneously: availability of variant homozygous or heterozygous genotypes of GRIA1 gene (rs545098) and SLC2A1 gene (rs841839), under the condition of simultaneous detection in the patient of excess content of aluminum in urine in more than 1.3 times as compared to the reference, the presence of asthenic-vegetative syndrome in conditions of aluminum exposure is diagnosed in a child.;EFFECT: invention provides reliable establishment at an early stage of assessing the effect of aluminum on the onset of asthenic-vegetative syndrome by using an aggregate of genetic markers and aluminum content in urine as an informative criterion.;1 cl, 2 tbl, 2 ex