METHOD FOR DETERMINING THRESHOLD OF PAIN SENSITIVITY OF LABORATORY ANIMALS AND DEVICE FOR ITS IMPLEMENTATION

摘要

FIELD: medicine.;SUBSTANCE: method for determining the threshold of pain sensitivity of laboratory animals is carried out using a device. Device for determining threshold of pain sensitivity of laboratory animals includes electrified floor of cell (2), electronic unit interfaced with computer (8). Electrified floor of the cell is made of conductive current bars. Electronic unit comprises electronic switches (1), keys control register (3), controlled constant voltage source (4), control automatic device (6) and USB controller (9). Each electronic switch is connected to a certain register bit. Each cage floor is connected via electronic switch with controlled source of constant voltage. Register and voltage source are connected to control unit connected to computer via USB controller. Animals are exposed to direct-current pulses with automatically controlled amplitude and duration, by controlled supply of pulses to each current-carrying rod of cell floor with phasing. Avoidance of current exposure to animals is excluded. Result of measurements is automatically saved in computer.;EFFECT: accurate, reliable and effective determination of a minimum threshold of pain sensitivity of animals due to possibility of smooth and accurate regulation of parameters of electric action, automatic measurement and registration of parameters in case of primary nociceptive reaction of animal.;2 cl, 3 dwg