COVALENTLY LINKED CONJUGATES CHELICAR-ANTIBODY AGAINST CHELICAR AND USE THEREOF

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to biotechnology, specifically to a method for preparing conjugates of a therapeutic compound with a prolonged half-life, and can be used in medicine. A conjugate consisting of a therapeutic polypeptide containing 12-dimensional spiral peptide and a specific antibody bound by a disulphide bond is obtained.;EFFECT: invention is used to create pharmaceutical compositions with a prolonged active elimination half-life in vivo.;11 cl, 15 dwg, 4 tbl, 16 ex