CHIMERIC ANTIGEN RECEPTORS SPECIFIC FOR THYMIC STROMAL LYMPHOPOIETIN RECEPTOR, AND METHODS FOR USE THEREOF

摘要

FIELD: medicine; pharmaceuticals.;SUBSTANCE: present invention relates to immunology. Disclosed is a chimeric antigenic receptor (CAR) containing an antigen-binding domain specific for thymic stromal lymphopoietin receptor (TSLPR), a transmembrane domain and an intracellular domain of T-cell signaling. Also disclosed is a CAR coding nucleic acid, a vector, a host cell, a cell population, a pharmaceutical composition, a method for detecting cancer, methods of treating or preventing cancer and proliferative disorder and a method for determining whether a subject with a proliferative disease is a candidate for treating the aforesaid CAR.;EFFECT: present invention can find further application in adoptive therapy of various diseases associated with a mutation in the IKZF gene and characterized by high expression of TSLPR, such as acute lymphoblastic leukemia (ALL).;30 cl, 26 dwg, 3 tbl, 2 ex