ORTHOGONAL PROTEINS Cas9 FOR RNA-DIRECTED REGULATION AND EDITING OF GENES

摘要

FIELD: biotechnologies.;SUBSTANCE: invention relates to the biotechnology. Described are methods for modulating expression of target nucleic acid in a cell, involving use of a plurality of orthogonal Cas9 proteins in order to simultaneously and independently regulate corresponding genes or simultaneously and independently edit corresponding genes.;EFFECT: invention extends the range of agents aimed at activating gene expression.;24 cl, 17 dwg, 1 tbl, 20 ex