Quantitative acetaminophen analysis

摘要

In order to provide a method for quantitatively determining the amount of acetaminophen in a sample with higher precision, higher sensitivity, and fewer interactions and less spectral and chemical interference with other compounds contained in the sample, a method is proposed according to the invention in which acetaminophen is hydrolyzed and the reacting therefrom p-aminophenol with a compound of general formula (III) in the presence of an oxidizing agent, wherein R1 and R2 are independently selected from H, -CH, and -OCH, R3 is -CH and R4 is a C-alkyl radical having one terminal Sulfonate group, with the proviso that at least one of R1 and R2 -OCHist and / or R4 additionally has at least one OH substituent, and then determines the amount of the compound of general formula (IV) in the reaction mixture photometrically.