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SRM/MRM ASSAY FOR THE SERINE/THREONINE-PROTEIN KINASE B-RAF (BRAF)
SRM/MRM ASSAY FOR THE SERINE/THREONINE-PROTEIN KINASE B-RAF (BRAF)
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机译:丝氨酸/苏氨酸蛋白激酶B-RAF(BRAF)的SRM / MRM检测
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摘要
The current disclosure provides for specific peptides, and derived ionization characteristics of the peptides, from the Serine/Threoninc-Protein Kinase B-raf (BRAF) that are particularly advantageous for quantifying the BRAF protein directly in bio-logical samples that have been fixed in formalin by the method of Selected Reaction Monitoring (SRM) mass spectrometry, or what can also be termed as Multiple Reaction Monitoring (MRM) mass spectrometry. Such biological samples are chemically preserved and fixed where the biological sample is selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (FFPE) tissue/cells, FFPE tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
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