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SECRETORY IMMUNOGLOBULIN A (SIGA)-BINDING NUCLEIC ACID MOLECULE, SENSOR FOR SIGA ANALYSIS, AND ANALYSIS METHOD FOR SIGA
SECRETORY IMMUNOGLOBULIN A (SIGA)-BINDING NUCLEIC ACID MOLECULE, SENSOR FOR SIGA ANALYSIS, AND ANALYSIS METHOD FOR SIGA
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机译:结合了免疫球蛋白A(SIGA)的核酸分子,用于SIGA分析的传感器以及用于SIGA的分析方法
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摘要
The present invention provides a novel molecule that can be used for detection of sIgA. The sIgA-binding nucleic acid molecule of the present invention is characterized in that it binds to secretory immunoglobulin A (sIgA) with a dissociation constant of 37.7 nM or less, and preferably includes a polynucleotide consisting of any of base sequences of SEQ ID NOs: 1 to 12 or a partial sequence thereof, for example. According to the sIgA-binding nucleic acid molecule of the present invention, it is possible to detect sIgA in saliva.
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机译:本发明提供了可用于检测sIgA的新型分子。本发明的结合sIgA的核酸分子的特征在于其以37.7nM或更小的解离常数结合分泌性免疫球蛋白A(sIgA),并且优选地包括由SEQ ID NOs的任何碱基序列组成的多核苷酸:例如,图1至12或其部分序列。根据本发明的sIgA结合核酸分子,可以检测唾液中的sIgA。
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