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ASSESSMENT OF JAK-STAT3 CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
ASSESSMENT OF JAK-STAT3 CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
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机译:利用靶基因表达的数学模型评估JAK-STAT3细胞信号通路的活性
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摘要
The present invention relates to a computer-implemented method for inferring activity of a JAK-STAT3 cellular signaling pathway in a subject based on expression levels of three or more target genes of the JAK-STAT3 cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a JAK-STAT3 cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the JAK-STAT3 cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a JAK-STAT3 cellular signaling pathway in a subject, and to the use of such kits in performing the method.
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