Mathematical modeling of gene expression associated with Wnt signaling pathway in colorectal carcinoma

摘要

Colorectal carcinoma (CRC)is one of the most common causes of cancer death in Europe and the United States.In Japan,according to dietary habit change to Western style food,CRC is thought to increase in the future.In cancer cells of CRC,beta-catenin is known to accumulate in nucleus and cytoplasm because of aberration of Wnt signaling pathway.The well-known target genes of beta-catenin are cyclin Dl and c-myc;the former is a cell cycle-related gene,the latter is an oncogene which contrails cell proliferation and apoptosis.Expression levels of these genes are upregulated by accumulation of beta-catenin.Thus,beta-catenin is one of the most important molecules of Wnt signaling.