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INHIBITION OF SCUBE2, A NOVEL VEGFR2 CO-RECEPTOR, SUPPRESSES TUMOR ANGIOGENESIS
INHIBITION OF SCUBE2, A NOVEL VEGFR2 CO-RECEPTOR, SUPPRESSES TUMOR ANGIOGENESIS
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机译:新型VEGFR2共同受体SCUBE2的抑制可抑制肿瘤血管生成。
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摘要
An isolated anti-SCUBE2 (Signal peptide-complement protein Clr/CIs, Uegf: and Bmp 1 (CUB)-epidermal growth factor (EGF) domain-containing protein 2) antibody or a binding fragment thereof is disclosed. The anti-SCUBE2 antibody comprises an antigen binding region that specifically hinds to a target domain located within SCUBE2 (SEQ ID NO: 66) and exhibits a property of inhibiting vascular endothelial growth factor (VEGF)-induced angiogenesis. The target domain is selected from the group consisting of the EGF-like motifs 4 to 6 ranging from a.a. position 175 to 323, or the spacer region ranging from a.a. position 441 to 659, or the first cys-rich motif ranging from a.a. position 668 to 725 of SCUBE2 (SEQ ID NO: 66). The anti-SCUBE2 antibody or binding fragment thereof is for use in treating a disease associated with VEGF-induced angiogenesis, or in treating a tumor or inhibiting tumor angiogenesis and cancer cell growth in a subject in need thereof.
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机译:公开了分离的抗SCUBE2(信号肽补体蛋白Clr / CIs,Uegf:和含有Bmp 1(CUB)-表皮生长因子(EGF)域的蛋白2)抗体或其结合片段。抗SCUBE2抗体包含特异地阻碍位于SCUBE2内的靶结构域的抗原结合区(SEQ ID NO:66),并表现出抑制血管内皮生长因子(VEGF)诱导的血管生成的特性。靶结构域选自由a.a.组成的EGF样基序4至6。位置175到323,或间隔范围为a.a. 441至659位,或第一个富含cys的基序,范围从a.a. SCUBE2(SEQ ID NO:66)的668至725位。抗SCUBE2抗体或其结合片段用于在需要其的受试者中治疗与VEGF诱导的血管生成有关的疾病,或用于治疗肿瘤或抑制肿瘤血管生成和癌细胞生长。
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