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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS AUTOLYSIN E, METHOD OF PRODUCING THE CRYSTAL AND ITS USE IN SCREENING METHODS

机译：金黄色葡萄球菌自溶酶E的晶体结构，制备方法及其在筛选方法中的应用

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摘要

The invention concerns the determination and evaluation of the crystal structure of autolysin E (AtlE) of Staphylococcus aureus (S. aureus), or a crystallizable fragment of AtlE, a method for producing a crystal of AtlE and the respective crystallization kit, and its use in a method for screening an inhibitor of the N-acetylglucosaminidase activity of AtlE, for obtaining atomic spatial relationship data, and for identifying a binding compound of AtlE, e.g. by in silico screening.

机译：本发明涉及金黄色葡萄球菌（S.aureus）的自溶素E（AtlE）或AtlE的可结晶片段的晶体结构的测定和评估，AtlE的晶体的生产方法和相应的结晶试剂盒及其用途在用于筛选AtlE的N-乙酰氨基葡糖苷酶活性的抑制剂，获得原子空间关系数据以及鉴定AtlE的结合化合物的方法中，例如通过计算机筛选。

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公开/公告号EP3289078B1

专利类型
公开/公告日2020-11-04

原文格式PDF
申请/专利权人 J. STEFAN INSTITUTE;
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申请/专利号EP20150722653
发明设计人 MIHELIC MARKO;RENKO MIHA;TURK DUSAN;
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申请日2015-04-27
分类号C12N9/36;A61K39/085;
国家 EP
入库时间 2022-08-21 11:39:23

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