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COMPOSITION FOR PREVENTION OR TREATMENT OF SPINOCEREBELLAR ATAXIA TYPE 36
COMPOSITION FOR PREVENTION OR TREATMENT OF SPINOCEREBELLAR ATAXIA TYPE 36
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机译:预防或治疗36型脊椎小动脉失弛缓症的组合物
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摘要
An object of the present invention is to provide ASO that can effectively suppress a formation of RNA foci spontaneously occurring in neurons having SCA36 mutation, without inducing the cleavage of NOP56 pre-mRNA. The present invention provides an oligonucleotide comprising a nucleotide sequence in which one or more nucleotide sequences represented by SEQ ID NO: 2 are consecutively connected and is complementary to pre-mRNA of NOP56 gene, wherein a structure formed by the hybridization of the oligonucleotide to the pre-mRNA is resistant to RNaseH.
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机译:本发明的目的是提供一种ASO,其可以有效地抑制在具有SCA36突变的神经元中自发出现的RNA灶的形成,而不会诱导NOP56前mRNA的裂解。本发明提供了一种寡核苷酸,其包含其中SEQ ID NO:2表示的一个或多个核苷酸序列连续连接并与NOP56基因的pre-mRNA互补的核苷酸序列,其中通过寡核苷酸与DNA的杂交形成的结构。前mRNA对RNaseH具有抗性。
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