A METHOD AND SYSTEM FOR GENE SIGNATURE MARKER SELECTION

摘要

A method (100) comprising: (i) providing (104, 106) a reference data set for a first gene expression platform and a training data set for a second platform; (iii) computing (108) a boundary expression level that distinguishes between the subtypes; (iv) generating (1 10) a confusion matrix; (v) determining (112) an effectiveness of the gene markers to discriminate between the subtypes; (vi) filtering (114) any gene marker with an expression level below a threshold or with determined effectiveness below a threshold; (v) calculating (118) a mean and/or median expression level for each subtype, and comparing them to generate an expression level change; (vi) comparing (118) the expression level change to a reference expression level change; and (vii) selecting (120) the gene marker if the generated expression level change and the reference expression level change are changed in the same direction; and (viii) providing (124) the selected gene markers via a user interface.