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NEW APPLICATIONS OF RIFAMYCIN-NITROIMIDAZOLE COUPLING MOLECULES
NEW APPLICATIONS OF RIFAMYCIN-NITROIMIDAZOLE COUPLING MOLECULES
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机译:利福霉素-亚硝基咪唑偶联分子的新应用
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摘要
The present invention discloses a use of a rifamycin-nitroimidazole conjugate molecule shown in formula I against anaerobic bacteria. The rifamycin-nitroimidazole conjugate molecule shown in formula I of the present invention has broad-spectrum antibacterial activity against anaerobic bacteria, including activity against most pathogenic bacteria associated with bacterial vaginosis, in vitro antibacterial activity stronger than that of drugs against bacterial vaginosis such as metronidazole and clindamycin, and potential use in prevention and treatment of bacterial vaginosis or other related diseases caused by anaerobic bacteria.展开▼
机译:本发明公开了式I所示的利福霉素-硝基咪唑共轭分子在抗厌氧细菌中的用途。本发明的式I所示的利福霉素-硝基咪唑共轭分子具有对厌氧菌的广谱抗菌活性,包括对大多数与细菌性阴道病有关的致病菌的活性,其体外抗菌活性强于对细菌性阴道病的药物如甲硝唑。和克林霉素,并潜在地用于预防和治疗由厌氧菌引起的细菌性阴道病或其他相关疾病。 <图像文件=“ IMGA0001.GIF” he =“ 58” imgContent =“ chem” imgFormat =“ GIF” wi =“ 137” /> Chemistry>
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