Blood-brain barrier transport molecules and their use

摘要

PROBLEM TO BE SOLVED: To provide a transporter molecule capable of transporting a target drug through the blood-brain barrier. An isolated transporter molecule comprising an immunoglobulin polypeptide, each polypeptide comprising a specific amino acid sequence, comprising an immunoglobulin heavy chain complementarity determining region-1 (H-CDR1), an immune domain. Globulin heavy chain complementarity determining region-2 (H-CDR2), immunoglobulin heavy chain complementarity determining region-3 (H-CDR3), immunoglobulin light chain complementarity determining region-1 (L-CDR1), immunoglobulin light A transporter comprising a chain complementarity determining region-2 (L-CDR2) and an immunoglobulin light chain complementarity determining region-3 (L-CDR3), wherein the transporter molecule is capable of crossing the blood brain barrier. molecule. [Selection diagram] Figure 1