Activators of autophagy flow and clearance of protein aggregates containing phospholipase D and tau and methods of treating proteinosis

摘要

PROBLEM TO BE SOLVED: To provide a compound which is an activator of an autophagy flow and a pharmaceutical composition containing the activator. A compound of the following formula. In the formula, R1 is a substituted thioheteroaryl, a substituted thiocycloalkyl, said compound, or a salt thereof, an enantiomer, a racemate, a mixture thereof, or a combination thereof. Use of the above compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, especially proteinosis such as Alzheimer's disease and tauopathy. How to increase the flow of autophagy. [Selection diagram] Fig. 1