Nucleotide excision repair inhibitor, tumor treatment enhancer and antitumor agent containing it

摘要

PROBLEM TO BE SOLVED: To contain a nucleotide removal / repair inhibitor having a simple chemical structure, which is easily available in large quantities, has a strong activity of inhibiting the removal / repair of damaged nucleotides, has low toxicity and is highly safe. Provided are enhancers and antitumor agents used for the treatment of tumors that damage the DNA of tumor cells such as cancer cells of the primary lesion. SOLUTION: The following lactone compound (1) and the following naphthoquinone compound (3), or a pharmaceutically acceptable salt thereof are contained. Tumor treatment enhancers and antitumor agents contain this nucleotide excision repair inhibitor as an active ingredient. [Selection diagram] None