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A novel group of Stat3 pathway inhibitors and cancer stem cell pathway inhibitors

机译:一组新的Stat3途径抑制剂和癌症干细胞途径抑制剂

摘要

PROBLEM TO BE SOLVED: To provide a Stat3 pathway inhibitor for treating a condition. The present invention uses a novel class of cancer stem cell pathway (CSPP) inhibitor; treatment-resistant, recurrent or metastatic. How to use such compounds to treat cancer; how to use such compounds in specific dosing regimens to selectively kill cancer cells; how to target cancer stem cells by inhibiting the Stat3 pathway How to use novel compounds in the treatment of mammalian conditions or disorders associated with abnormal Stat3 pathway activity; and how to prepare such compounds and their intermediates, as well as pharmaceutical compositions of related compounds, and compounds thereof. Regarding the specific administration method of. [Selection diagram] None
机译:要解决的问题:提供用于治疗疾病的Stat3途径抑制剂。本发明使用新型的癌症干细胞途径(CSPP)抑制剂。耐治疗,复发或转移。如何使用此类化合物治疗癌症;如何在特定的给药方案中使用此类化合物以选择性杀死癌细胞;如何通过抑制Stat3途径靶向癌症干细胞。如何使用新型化合物治疗与Stat3途径异常活动相关的哺乳动物疾病或病症;以及如何制备此类化合物及其中间体,以及相关化合物的药物组合物,及其化合物。关于具体的给药方法。 [选择图]无

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