2-(4-chlorophenoxy)-N-((1-(2-(4-chlorophenoxy)ethynazetidin-3-yl)methyl) as an ATF4 inhibitor for treating cancer and other diseases Acetamide derivatives and related compounds

摘要

The present invention is directed to substituted azetidine derivatives. Specifically, the present invention relates to compounds according to formula I (in the formula, C, D, L1, L2, L3, R1, R2, R4, R5, R6, z2, z4, z5, and z6. As defined). The present invention further covers pharmaceutical compositions comprising the compounds of the present invention. The present invention also further uses methods of inhibiting the ATF4 (Activating Transcription Factor 4) pathway and associated disorders such as cancer, using the compounds of the invention or pharmaceutical compositions comprising the compounds of the invention. It targets the treatment of neurodegenerative diseases and many other diseases. Preferred compounds of the present invention are 2- (4-chlorophenoxy) -N-((1- (2- (4-chlorophenoxy) ethynazetidine-3-yl) methyl) acetamide derivatives and related compounds.