2-(4-CHLOROPHENOXY)-N-((1 -(2-(4-CHLOROPHENOXY)ETHYNAZETIDIN-3-YL)METHYL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES

摘要

The invention is directed to substituted azetidine derivatives. Specifically, the invention is directed to compounds according to Formula I:; ;wherein C, D, L¹, L², L³, R¹, R², R⁴, R⁵, R⁶, z², z⁴, z⁵, and z⁶ are as defined herein; and salts thereof.;The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting the ATF4 pathway and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.