Methods for treating hot flashes in a subject are disclosed herein. In one embodiment, hot flash treatment administers a therapeutically effective amount of a transient receptor potential channel (TRP channel) blocker or a pharmaceutically acceptable salt thereof to a subject in need of such treatment. Including that. It also comprises selecting a subject in need of hot flash treatment, administering a therapeutically effective amount of a TRP channel blocker, such as a TRPV1 blocker, or a pharmaceutically acceptable salt thereof to the subject. Methods for improving, reducing, or preventing hot flashes in hot flashes are also disclosed herein.
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